Irf8^tm1Hor
Targeted Allele Detail

Summary

• Symbol: Irf8^tm1Hor
• Name: interferon regulatory factor 8; targeted mutation 1, Ivan Horak
• MGI ID: MGI:1926332
• Synonyms: ICSBP-, IRF-8-
• Gene: Irf8 Location: Chr8:121463097-121483433 bp, + strand Genetic Position: Chr8, 70.05 cM
• Alliance: Irf8^tm1Hor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36038
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK-neomycin gene was inserted into the second exon, disrupting sequences encoding the DNA binding domain. (J:36038)

Disease models

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Irf8^tm1Hor

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Irf8 Mutation: 32 strains or lines available

References

• Original: J:36038 Holtschke T, et al., Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell. 1996 Oct 18;87(2):307-17
• All: 107 reference(s)