Stat3^tm2Aki
Targeted Allele Detail

Summary

• Symbol: Stat3^tm2Aki
• Name: signal transducer and activator of transcription 3; targeted mutation 2, Shizuo Akira
• MGI ID: MGI:1926816
• Synonyms: Stat3^cKO, Stat3^flox, Stat3^flx, STAT3^lox, Stat3^loxP, STAT3-loxP
• Gene: Stat3 Location: Chr11:100777632-100830447 bp, - strand Genetic Position: Chr11, 63.82 cM
• Alliance: Stat3^tm2Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50443
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Insertion of loxP sites flanking exons encoding the tyrosine phosphorylation site. No phenotypic effect on the function of the Stat3 gene. (J:50443)

Expression

In Mice Carrying this Mutation:	5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stat3 Mutation: 72 strains or lines available

References

• Original: J:50443 Takeda K, et al., Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J Immunol. 1998 Nov 1;161(9):4652-60
• All: 272 reference(s)