Atm^tm1Led
Targeted Allele Detail

Summary

• Symbol: Atm^tm1Led
• Name: ataxia telangiectasia mutated; targeted mutation 1, Philip Leder
• MGI ID: MGI:1926875
• Synonyms: Atm -
• Gene: Atm Location: Chr9:53350449-53448040 bp, - strand Genetic Position: Chr9, 29.12 cM, cytoband C-D
• Alliance: Atm^tm1Led page

Cross section through seminiferous tubule of +/+ and Atm^tm1Led/Atm^tm1Led mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36561
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK-neomycin cassette was inserted into a coding exon of the mouse Atm gene. The insertion position corresponds to nt 5640 of the human ATM cDNA. (J:36561)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Atm^tm1Led

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atm Mutation: 170 strains or lines available

References

• Original: J:36561 Elson A, et al., Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13084-9
• All: 32 reference(s)