H2-Ab1^b-tm1Doi
Targeted Allele Detail

Summary

• Symbol: H2-Ab1^b-tm1Doi
• Name: histocompatibility 2, class II antigen A, beta 1; targeted mutation 1, Christophe Benoist and Diane Mathis
• MGI ID: MGI:1927483
• Synonyms: AB0, A^bbeta^-, Abeta-, A beta⁰, Class II⁰, H2-Ab1^tm1Dim, H2-Ab1^tm1Doi, H2-Ab1tm1Doi, II⁰, MHC class II-, MHCII^-, MHC-II-k.o.
• Gene: H2-Ab1 Location: Chr17:34482201-34488392 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: H2-Ab1^b-tm1Doi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65736
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The second exon was disrupted by the insertion of a neomycin resistance gene. In addition, the ES cell line used was derived from the 129S2/SvPas strain, which carries a deletion in the promoter region of H2-Ea. Consequently, these MHC class II molecule-deficient mice lacked cell surface expression of both class II-A and class II-E MHC proteins. (J:65736)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 24 strains available Cell Lines: 0 lines available
• Carrying any H2-Ab1 Mutation: 83 strains or lines available

References

• Original: J:65736 Cosgrove D, et al., Mice lacking MHC class II molecules. Cell. 1991 Sep 6;66(5):1051-66
• All: 176 reference(s)