Stat1^tm1Dlv
Targeted Allele Detail

Summary

• Symbol: Stat1^tm1Dlv
• Name: signal transducer and activator of transcription 1; targeted mutation 1, David E Levy
• MGI ID: MGI:1930947
• Synonyms: STAT^-, Stat1-, STAT1-, Stat1 KO
• Gene: Stat1 Location: Chr1:52158599-52201024 bp, + strand Genetic Position: Chr1, 26.81 cM
• Alliance: Stat1^tm1Dlv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31325
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 5.7 kb of sequence, including 3 exons and a portion of a fourth encoding amino acids 221-365. This allele produces a partial nonfunctional protein product. (J:31325)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Stat1^tm1Dlv

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 6 strains available Cell Lines: 0 lines available
• Carrying any Stat1 Mutation: 74 strains or lines available

References

• Original: J:31325 Durbin JE, et al., Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell. 1996 Feb 9;84(3):443-50
• All: 248 reference(s)