Csf2^tm1Mlg
Targeted Allele Detail

Summary

• Symbol: Csf2^tm1Mlg
• Name: colony stimulating factor 2 (granulocyte-macrophage); targeted mutation 1, Richard C Mulligan
• MGI ID: MGI:1930996
• Synonyms: Csf2^-, Csf2^tm1Jaw, GM-, GM-CSF-, GM-CSF KO
• Gene: Csf2 Location: Chr11:54138097-54140493 bp, - strand Genetic Position: Chr11, 32.13 cM
• Alliance: Csf2^tm1Mlg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:17978
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 3 and 4 and flanking intronic sequence were replaced by a neomycin cassette. (J:17978)

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Csf2^tm1Mlg

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Csf2 Mutation: 35 strains or lines available

References

• Original: J:17978 Dranoff G, et al., Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. Science. 1994 Apr 29;264(5159):713-6
• All: 92 reference(s)