H2-D1^b-tm1Bpe
Targeted Allele Detail

Summary

• Symbol: H2-D1^b-tm1Bpe
• Name: histocompatibility 2, D region locus 1; targeted mutation 1, Beatrice Perarnau
• MGI ID: MGI:1931445
• Synonyms: D^-, D^b-, H2-D1^tm1Bpe, H-2D^b-, H-2D^b knockout, H-2 D^bo, H-2D^o, HHD
• Gene: H2-D1 Location: Chr17:35482070-35486473 bp, + strand Genetic Position: Chr17, 18.61 cM
• Alliance: H2-D1^b-tm1Bpe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41077
• Parent Cell Line: CGR8 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1, 2 and 3 of the b haplotype gene were replaced with plasmid sequences and a neomycin cassette. (J:41077)

Expression

In Mice Carrying this Mutation:

45 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 10 strains available Cell Lines: 0 lines available
• Carrying any H2-D1 Mutation: 47 strains or lines available

References

• Original: J:41077 Pascolo S, et al., HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice. J Exp Med. 1997 Jun 16;185(12):2043-51
• All: 162 reference(s)