Gpr143^tm1Inc
Targeted Allele Detail

Summary

• Symbol: Gpr143^tm1Inc
• Name: G protein-coupled receptor 143; targeted mutation 1, Barbara Incerti
• MGI ID: MGI:1931862
• Synonyms: Oa1-
• Gene: Gpr143 Location: ChrX:151564917-151591642 bp, + strand Genetic Position: ChrX, 68.46 cM, cytoband F2-F3
• Alliance: Gpr143^tm1Inc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66139
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-hprt expression cassette replaced exon 1 including the start codon of the gene. Several human mutations are located in the corresponding human exon 1. Northern analysis of primary melanocyte cultures did not detect transcript in homozygous mutant neonates. (J:66139)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gpr143 Mutation: 14 strains or lines available

References

• Original: J:66139 Incerti B, et al., Oa1 knock-out: new insights on the pathogenesis of ocular albinism type 1. Hum Mol Genet. 2000 Nov 22;9(19):2781-8
• All: 8 reference(s)