Cryge^Aey1
Chemically induced Allele Detail

Summary

• Symbol: Cryge^Aey1
• Name: crystallin, gamma E; nuclear and zonular cataract
• MGI ID: MGI:1932397
• Gene: Cryge Location: Chr1:65087713-65090308 bp, - strand Genetic Position: Chr1, 32.8 cM
• Alliance: Cryge^Aey1 page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A transversion of an A at position 1 of the cDNA to a T. This results in expression from an ATG 19 bp downstream. The phase of this ORF is shifted +1 to produce a novel protein, which may interfere with the normal structural organization of the lens. (J:67888)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cryge Mutation: 25 strains or lines available

References

• Original: J:68708 Hrabe de Angelis MH, et al., Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet. 2000 Aug;25(4):444-7
• All: 3 reference(s)