Cln3^tm1Nbm
Targeted Allele Detail

Summary

• Symbol: Cln3^tm1Nbm
• Name: CLN3 lysosomal/endosomal transmembrane protein, battenin; targeted mutation 1, Robert L Nussbaum
• MGI ID: MGI:1933976
• Synonyms: Cln3-, Cln-3^deltaex1-6
• Gene: Cln3 Location: Chr7:126170571-126184991 bp, - strand Genetic Position: Chr7, 69.16 cM
• Alliance: Cln3^tm1Nbm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58230
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-6 and most of exon 1, including the start codon of the Cln3 gene were replaced with a neomycin resistance gene transcribed in the reverse orientation from a mouse PGK promoter. (J:55232, J:58230)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Cln3 Mutation: 38 strains or lines available

References

• Original: J:58230 Mitchison HM, et al., Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. Neurobiol Dis. 1999 Oct;6(5):321-34
• All: 41 reference(s)