Il18r1^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Il18r1^tm1Aki
• Name: interleukin 18 receptor 1; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:2136765
• Synonyms: Il18r1-, Il18ralpha-, Il1rrp^tm1Aki
• Gene: Il18r1 Location: Chr1:40504712-40540014 bp, + strand Genetic Position: Chr1, 19.27 cM, cytoband B
• Alliance: Il18r1^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70298
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of the exon encoding amino acids 296-350, encoding the transmembrane region, with a neomycin cassette. No mRNA was detected in liver from homozygous mutant animals, as assayed by RT-PCR. (J:70298)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il18r1 Mutation: 45 strains or lines available

References

• Original: J:70298 Hoshino K, et al., Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor. J Immunol. 1999 May 1;162(9):5041-4
• All: 104 reference(s)