Crybb2^Aey2
Chemically induced Allele Detail

Summary

• Symbol: Crybb2^Aey2
• Name: crystallin, beta B2; cortical and anterior suture opacity
• MGI ID: MGI:2137511
• Gene: Crybb2 Location: Chr5:113206124-113217983 bp, - strand Genetic Position: Chr5, 55.38 cM
• Alliance: Crybb2^Aey2 page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A T-to-A transversion at position 553 (exon 6). This mutation is predicted to lead to a valine to glutamic acid substitution at codon 187, which may disrupt the formation of the fourth Greek key motif of the protein. (J:70508)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crybb2 Mutation: 13 strains or lines available

References

• Original: J:70508 Graw J, et al., Aey2, a new mutation in the betaB2-crystallin-encoding gene of the mouse. Invest Ophthalmol Vis Sci. 2001 Jun;42(7):1574-80
• All: 3 reference(s)