Nbn^tm1Nus
Targeted Allele Detail

Summary

• Symbol: Nbn^tm1Nus
• Name: nibrin; targeted mutation 1, Andre Nussenzweig
• MGI ID: MGI:2156049
• Synonyms: NBS1-
• Gene: Nbn Location: Chr4:15957925-15992589 bp, + strand Genetic Position: Chr4, 6.66 cM, cytoband A
• Alliance: Nbn^tm1Nus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68993
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 2kb of gene sequence spanning the promoter, exon 1 (including the translation initiation codon), and 700 bp of intron 1. (J:68993)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nbn Mutation: 59 strains or lines available

References

• Original: J:68993 Zhu J, et al., Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice. Curr Biol. 2001 Jan 23;11(2):105-9
• All: 5 reference(s)