Im1^Bioz:BP1
QTL Variant Detail

Summary

• QTL variant: Im1^Bioz:BP1
• Name: Immunoregulatory 1; Bioz:BP1
• MGI ID: MGI:2157088
• Synonyms: high antibody responder, Im1^H
• QTL: Im1 Location: Chr8:116828531-116828668 bp Genetic Position: Chr8, cM position of peak correlated region/allele: 62.82 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: Bioz:BP1

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased antibody response compared to Bioz:BP1. (J:46394)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:46394

Im1 (immunoregulatory), a QTL affecting antibody response, was mapped from cM range 41 to 71 range on mouse chromosome 8 (P=5.1 x 10-4 at D8Mit35). Animals from a high (H) antibody responder line x low (L) antibody responder line F2 intercross were successively backcrossed to the L line to localize the QTL.Im3 a suggestive QTL (P = 1.1 x 10-2) was also identified on mouse Chromosome 8 at approximately 30 cM - 33.5 cM associated with D8Mit9. Im appears to have a greater effect in later antibody response(14 days v 5 days post-innoculation) as well as a greater effect in female animals.

J:37251

High(H) and Low(L) antibody responder lines of Biozzi mice were used in mapping Im loci. (H x L)F1 x L mice were informative in mapping Im1 with D8Mit35.

References

• Original: J:46394 Puel A, et al., Identification of two quantitative trait loci involved in antibody production on mouse chromosome 8. Immunogenetics. 1998 Mar;47(4):326-31
• All: 2 reference(s)