Il1b^tm1Yiw
Targeted Allele Detail

Summary

• Symbol: Il1b^tm1Yiw
• Name: interleukin 1 beta; targeted mutation 1, Yoichiro Iwakura
• MGI ID: MGI:2157396
• Synonyms: Il-1b^-, IL-1beta-, Il-1beta KO
• Gene: Il1b Location: Chr2:129206490-129213059 bp, - strand Genetic Position: Chr2, 62.97 cM, cytoband F
• Alliance: Il1b^tm1Yiw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47429
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-PGK-neomycin resistance cassette replaced part of exon 3, all of exon 4, and part of exon 5, including sequences encoding the amino terminus of the mature protein. Northern blot analysis of activated peritoneal macrophages did not detect transcript in homozygous mutant mice. (J:47429, J:92002)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il1b Mutation: 25 strains or lines available

References

• Original: J:47429 Horai R, et al., Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion. J Exp Med. 1998 May 4;187(9):1463-75
• All: 198 reference(s)