Ccr2^tm1Ifc
Targeted Allele Detail

Summary

• Symbol: Ccr2^tm1Ifc
• Name: C-C motif chemokine receptor 2; targeted mutation 1, Israel F Charo
• MGI ID: MGI:2158213
• Synonyms: CCR2-, CCR2^-, Cmkbr2^tm1Kuz
• Gene: Ccr2 Location: Chr9:123901987-123913594 bp, + strand Genetic Position: Chr9, 75.05 cM, cytoband F
• Alliance: Ccr2^tm1Ifc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44345
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region and 3' untranslated region are replaced with a polII-neo cassette. Absence of transcript was confirmed by RT-PCR using mRNA isolated from spleens and thioglycolate elicited peritoneal exudate cells of homozygous mutant animals. (J:44345)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ccr2^tm1Ifc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccr2 Mutation: 43 strains or lines available

References

• Original: J:44345 Boring L, et al., Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J Clin Invest. 1997 Nov 15;100(10):2552-61
• All: 466 reference(s)