Bdkrb1^tm1Bdr
Targeted Allele Detail

Summary

• Symbol: Bdkrb1^tm1Bdr
• Name: bradykinin receptor, beta 1; targeted mutation 1, Michael Bader
• MGI ID: MGI:2158501
• Synonyms: B1 -, B1-KO, B1R^-, B1 receptor-deficient
• Gene: Bdkrb1 Location: Chr12:105570350-105571770 bp, + strand Genetic Position: Chr12, 55.81 cM, cytoband F1
• Alliance: Bdkrb1^tm1Bdr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63271
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into the coding region of the gene. RNAse protection assays on RNA derived from various tissues of homozygous mice demonstrated that no detectable transcript was produced from this allele. A specific agonist of the encoded receptor failed to elicit responses in isolated ileum from homozygous mice, confirming that no functional protein is produced from this allele. (J:63271)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bdkrb1 Mutation: 22 strains or lines available

References

• Original: J:63271 Pesquero JB, et al., Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors [see comments]. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8140-5
• All: 37 reference(s)