Casp4^tm1Yuan
Targeted Allele Detail

Summary

• Symbol: Casp4^tm1Yuan
• Name: caspase 4, apoptosis-related cysteine peptidase; targeted mutation 1, Junying Yuan
• MGI ID: MGI:2159366
• Synonyms: casp-11, Casp11^-, Caspase-11-
• Gene: Casp4 Location: Chr9:5308828-5336783 bp, + strand Genetic Position: Chr9, 2.46 cM, cytoband A1
• Alliance: Casp4^tm1Yuan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46167
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a 1.5 kb genomic fragment containing sequences encoding 16 amino acids of the active site. Western blot analysis on lysates derived from spleen of both LPS-injected and control homozygous mice confirmed that no detectable protein is expressed from this allele. (J:46167)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Casp4 Mutation: 33 strains or lines available

References

• Original: J:46167 Wang S, et al., Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell. 1998 Feb 20;92(4):501-9
• All: 63 reference(s)