Tg(Syn1-cre)671Jxm
Transgene Detail

Summary

• Symbol: Tg(Syn1-cre)671Jxm
• Name: transgene insertion 671, Jamey Marth
• MGI ID: MGI:2176055
• Synonyms: cre^syn1, Syn-cre, Syn-Cre^tg, SynI-Cre
• Transgene: Tg(Syn1-cre)671Jxm Location: unknown Genetic Position: Chr6, Syntenic
• Alliance: Tg(Syn1-cre)671Jxm page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutations: Duplication, Insertion
• Tg(Syn1-cre)671Jxm expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Syn1 (24949)

  Syn1	(MGI:98460)

• Mutation details: This transgene expresses Cre recombinase under the control of a rat synapsin I promoter. Cre recombinase activity is detected in neuronal cells, including brain, spinal cord and DRGs, as early as E12.5, as well as in neurons in adult. Line 671 contains 10 copies of the transgene inserted into chromosome 6 over 1 Mb from the nearest gene (chr6:10,423,318; NCBI37/mm9) with a duplication of unknown size at the insertion site. (J:68558)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Syn1 (rat) Summary of all recombinase alleles driven by Syn1. Comparative matrix view of recombinase activities Alliance rat Syn1 gene page
User Notes:	Additional information submitted by the research community Additional information submitted by the research community It was reported by Rempe et al., 2006 (PMID 16419044) that transgene expression in male mice results in germline recombination in progeny.

Disease models

Expression

In Mice Carrying this Mutation:

3 assay results 2 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Syn1-cre)671Jxm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Homozygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.

References

• Original: J:68558 Zhu Y, et al., Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev. 2001 Apr 1;15(7):859-76
• All: 221 reference(s)