Eif4ebp1^tm1Nso
Targeted Allele Detail

Summary

• Symbol: Eif4ebp1^tm1Nso
• Name: eukaryotic translation initiation factor 4E binding protein 1; targeted mutation 1, Nahum Sonenberg
• MGI ID: MGI:2177923
• Synonyms: 4E-BP1 KO, Eif4ebp1-
• Gene: Eif4ebp1 Location: Chr8:27750355-27765684 bp, + strand Genetic Position: Chr8, 15.95 cM, cytoband A4-B1
• Alliance: Eif4ebp1^tm1Nso page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72217
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The splice acceptor site and the first 57 nucleotides of exon 2 were replaced with the neomycin-resistance gene. The disrupted portion of exon 2 encodes amino acids 47 to 66, which encompasses the binding site for EIF4E. (J:72217)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Eif4ebp1^tm1Nso

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Eif4ebp1 Mutation: 33 strains or lines available

References

• Original: J:72217 Tsukiyama-Kohara K, et al., Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat Med. 2001 Oct;7(10):1128-32
• All: 44 reference(s)