Tlr2^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Tlr2^tm1Aki
• Name: toll-like receptor 2; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:2178675
• Synonyms: Tlr2-, TLR2 KO, TLR2KO
• Gene: Tlr2 Location: Chr3:83743579-83749045 bp, - strand Genetic Position: Chr3, 37.4 cM
• Alliance: Tlr2^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76115
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaces the part of the exon that encodes the transmembrane and the cytoplasmic domain of this single exon gene. The absence of transcript was confirmed by Northern analysis of peritonel macrophages. (J:76115, J:91950)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Tlr2 Mutation: 60 strains or lines available

References

• Original: J:76115 Takeuchi O, et al., Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity. 1999 Oct;11(4):443-51
• All: 639 reference(s)