Cxcl10^tm1Adl
Targeted Allele Detail

Summary

• Symbol: Cxcl10^tm1Adl
• Name: C-X-C motif chemokine ligand 10; targeted mutation 1, Andrew D Luster
• MGI ID: MGI:2180678
• Synonyms: IP-10^-
• Gene: Cxcl10 Location: Chr5:92494497-92496748 bp, - strand Genetic Position: Chr5, 46.57 cM
• Alliance: Cxcl10^tm1Adl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75584
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-3, which encompass most of the coding region of the gene, were replaced with a PGK-neo cassette via homologous recombination. Northern and Western blot analyses of bone marrow macrophages confirmed the absence of gene expression in homozygous mutant animals. (J:75584)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cxcl10 Mutation: 21 strains or lines available

References

• Original: J:75584 Dufour JH, et al., IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. J Immunol. 2002 Apr 1;168(7):3195-204
• All: 63 reference(s)