Maoa^{Tg(H2-K1-Ifnb1)8Seif}
Transgenic Allele Detail

Summary

• Symbol: Maoa^{Tg(H2-K1-Ifnb1)8Seif}
• Name: monoamine oxidase A; transgene insertion 8, Isabelle Seif
• MGI ID: MGI:2180818
• Synonyms: MAO-A knockout, MAOA-KO, Maoa^{Tg(H2-IFNB)8Seif}, Tg8
• Gene: Maoa Location: ChrX:16485937-16554051 bp, + strand Genetic Position: ChrX, 11.78 cM, cytoband A2
• Alliance: Maoa^{Tg(H2-K1-Ifnb1)8Seif} page

Transgene origin

• Strain of Origin: C3H/HeOuJ

Transgene description

• Transgene Type: Transgenic (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Random integration of a transgene for IFN beta expressed under the control of a truncated H2-K1 promoter resulted in deletion of a 17 kb region encompassing exons 2 and 3 of the Maoa gene. Enzyme activity was absent in brain and spleen samples from mutant animals. (J:26232)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Maoa Mutation: 11 strains or lines available

References

• Original: J:26232 Cases O, et al., Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA [see comments]. Science. 1995 Jun 23;268(5218):1763-6
• All: 40 reference(s)