Tcra^tm1Mjo
Targeted Allele Detail

Summary

• Symbol: Tcra^tm1Mjo
• Name: T cell receptor alpha chain; targeted mutation 1, Michael J Owen
• MGI ID: MGI:2180883
• Synonyms: Calpha-, Tcralpha-, TCRalpha, TCRalphae^-, TCRalpha KO, Tcra^tm1Phi
• Gene: Tcra Location: Chr14:52665424-54461655 bp, + strand Genetic Position: Chr14, cytoband D1-D2

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:1292
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• The Tcra-C element C1 was disrupted by the insertion of a neomycin selection cassette. (J:1292)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Tcra Mutation: 101 strains or lines available

References

• Original: J:1292 Philpott KL, et al., Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells. Science. 1992 Jun 5;256(5062):1448-52
• All: 107 reference(s)