Otog^tm1Prs
Targeted Allele Detail

Summary

• Symbol: Otog^tm1Prs
• Name: otogelin; targeted mutation 1, Marie-Christine Simmler
• MGI ID: MGI:2181633
• Synonyms: Otog-
• Gene: Otog Location: Chr7:45890411-45960858 bp, + strand Genetic Position: Chr7, 29.66 cM, cytoband B4-C
• Alliance: Otog^tm1Prs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60193
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The majority of exon 1 and all of exons 2 and 3 were replaced with a NLS-lacZ and neo cassette inserted immediately downstream of the endogenous start codon. RT-PCR analysis of inner ear tissue showed an absence of transcript in homozygous mutant mice. Immunohistolabelling was reported to additionally confirm inactivation (data not shown). (J:60193)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Otog Mutation: 149 strains or lines available

References

• Original: J:60193 Simmler MC, et al., Targeted disruption of otog results in deafness and severe imbalance [see comments]. Nat Genet. 2000 Feb;24(2):139-43
• All: 4 reference(s)