Tg(GFP/KRAS2/ALPP)1Brn
Transgene Detail

Summary

• Symbol: Tg(GFP/KRAS2/ALPP)1Brn
• Name: transgene insertion 1, Anton Berns
• MGI ID: MGI:2182853
• Synonyms: beta-actin::LSL::^G12VKRAS, ^G12VKRAS, K-ras^{G12V-IRES-PLAP-pA}
• Transgene: Tg(GFP/KRAS2/ALPP)1Brn Location: unknown
• Alliance: Tg(GFP/KRAS2/ALPP)1Brn page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: A transgene consisting of a chicken beta actin promoter, followed by a GFP (green fluorescence protein) expression cassette flanked by two lox sites and preceding a human K-Ras^V12 cDNA combined with an ALPP (PLAP; human placenta-like alkaline phosphatase) expression construct. Expression of oncogenic K-Ras^V12 is dependent on Cre-mediated deletion of the GFP fragment. (J:72206)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(GFP/KRAS2/ALPP)1Brn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:72206 Meuwissen R, et al., Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene. Oncogene. 2001 Oct 4;20(45):6551-8
• All: 7 reference(s)