Gal^tm1Wyn
Targeted Allele Detail

Summary

• Symbol: Gal^tm1Wyn
• Name: galanin and GMAP prepropeptide; targeted mutation 1, David Wynick
• MGI ID: MGI:2183172
• Synonyms: galanin -, Gal KO, GALKO
• Gene: Gal Location: Chr19:3459915-3464544 bp, - strand Genetic Position: Chr19, 3.16 cM
• Alliance: Gal^tm1Wyn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78046
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 5 were replaced with a neomycin selection cassette. Protein encoded by the targeted locus was undetected by radioimmunoassays of homozygous mutant brain and peripheral tissues. (J:78046)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Gal Mutation: 23 strains or lines available

References

• Original: J:78046 Wynick D, et al., Galanin regulates prolactin release and lactotroph proliferation. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12671-6
• All: 27 reference(s)