Diablo^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Diablo^tm1Mak
• Name: diablo, IAP-binding mitochondrial protein; targeted mutation 1, Tak Mak
• MGI ID: MGI:2183277
• Synonyms: Smac^-, SMAC-KO
• Gene: Diablo Location: Chr5:123647828-123662239 bp, - strand Genetic Position: Chr5, 63.02 cM, cytoband F
• Alliance: Diablo^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76248
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exons 2-4 with a PGK-neo cassette via homologous recombination. The null allele was confirmed by Western blot analysis of mouse embryonic fibroblasts (MEFs) derived from E14.5 homozygous mutant embryos. No protein expression was detected. (J:76248)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Diablo Mutation: 13 strains or lines available

References

• Original: J:76248 Okada H, et al., Generation and characterization of Smac/DIABLO-deficient mice. Mol Cell Biol. 2002 May;22(10):3509-17
• All: 10 reference(s)