Tiam1^tm1Jgc
Targeted Allele Detail

Summary

• Symbol: Tiam1^tm1Jgc
• Name: T cell lymphoma invasion and metastasis 1; targeted mutation 1, John G Collard
• MGI ID: MGI:2183309
• Synonyms: Tiam1^-, Tiam KO
• Gene: Tiam1 Location: Chr16:89583999-89940657 bp, - strand Genetic Position: Chr16, 51.5 cM, cytoband C3-4
• Alliance: Tiam1^tm1Jgc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77148
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing both lacZ and neo genes was inserted in-frame in exon 2. Western blot analysis of homozygous mutant mice showed an absence of encoded protein in the cerebellum. Staining comparisons showed the expression of beta-galactosidase to be driven by the endogenous promoter. (J:77148)

Tumor Data

List all tumor models in MMHCdb carrying Tiam1^tm1Jgc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tiam1 Mutation: 73 strains or lines available

References

• Original: J:77148 Malliri A, et al., Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours. Nature. 2002 Jun 20;417(6891):867-71
• All: 16 reference(s)