Rad52^tm1Aps
Targeted Allele Detail

Summary

• Symbol: Rad52^tm1Aps
• Name: RAD52 homolog, DNA repair protein; targeted mutation 1, Albert Pastink
• MGI ID: MGI:2383953
• Synonyms: MmRAD52^-
• Gene: Rad52 Location: Chr6:119879659-119899789 bp, + strand Genetic Position: Chr6, 56.86 cM, cytoband G3
• Alliance: Rad52^tm1Aps page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50357
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a neomycin selection cassette. Western blot analysis of homozygous mutant ES cells showed an absence of both normal and truncated protein. (J:50357)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rad52 Mutation: 18 strains or lines available

References

• Original: J:50357 Rijkers T, et al., Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation. Mol Cell Biol. 1998 Nov;18(11):6423-9
• All: 9 reference(s)