Mapk8^tm1Wag
Targeted Allele Detail

Summary

• Symbol: Mapk8^tm1Wag
• Name: mitogen-activated protein kinase 8; targeted mutation 1, Erwin F Wagner
• MGI ID: MGI:2384141
• Synonyms: Jnk1^-
• Gene: Mapk8 Location: Chr14:33099855-33169115 bp, - strand Genetic Position: Chr14, 20.22 cM, cytoband B
• Alliance: Mapk8^tm1Wag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78190
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3' region of exon 2, which encodes a portion of the kinase domain, was deleted by the in frame insertion of a cassette containing lacZ along with neo. The absence of both known isoforms encoded by the endogenous locus was confirmed by Western blot analysis of homozygous mutant mouse embyronic fibroblasts. (J:78190)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mapk8 Mutation: 74 strains or lines available

References

• Original: J:78190 Sabapathy K, et al., c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation. J Exp Med. 2001 Feb 5;193(3):317-28
• All: 43 reference(s)