Csf3r^tm3Link
Targeted Allele Detail

Summary

• Symbol: Csf3r^tm3Link
• Name: colony stimulating factor 3 receptor; targeted mutation 3, Daniel C Link
• MGI ID: MGI:2384412
• Synonyms: d715F
• Gene: Csf3r Location: Chr4:125918343-125938233 bp, + strand Genetic Position: Chr4, 59.77 cM
• Alliance: Csf3r^tm3Link page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67612
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Two point mutations generated by site directed mutagenesis were introduced at this locus by homologous recombination. A nonsense mutation at nucleotide 2403 resulted in the truncation of 96 carboxy terminal residues. An additional mutation at nucleotide 2362 mutated codon 704 to encode a phenylalanine rather than a tyrosine. (J:67612)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Csf3r Mutation: 42 strains or lines available

References

• Original: J:67612 McLemore ML, et al., STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation. Immunity. 2001 Feb;14(2):193-204
• All: 6 reference(s)