Ltb4r1^tm1Adl
Targeted Allele Detail

Summary

• Symbol: Ltb4r1^tm1Adl
• Name: leukotriene B4 receptor 1; targeted mutation 1, Andrew D Luster
• MGI ID: MGI:2385786
• Synonyms: BLT1^-, BLTR^-
• Gene: Ltb4r1 Location: Chr14:56003419-56005951 bp, + strand Genetic Position: Chr14, 28.19 cM
• Alliance: Ltb4r1^tm1Adl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63873
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 2 just 3' of the translation initiation codon via homologous recombination. Northern blot analysis detected a mutant transcript containing the neomycin insert in neutrophils, macrophages, lymph nodes, lung, and spleen from homozygous mutant animals. (J:63873)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ltb4r1 Mutation: 20 strains or lines available

References

• Original: J:63873 Tager AM, et al., BLTR mediates leukotriene B(4)-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis [see comments]. J Exp Med. 2000 Aug 7;192(3):439-46
• All: 50 reference(s)