Nfe2l2^tm1Ywk
Targeted Allele Detail

Summary

• Symbol: Nfe2l2^tm1Ywk
• Name: nuclear factor, erythroid derived 2, like 2; targeted mutation 1, Yuet Wai Kan
• MGI ID: MGI:2385926
• Synonyms: Nrf2-, NRF2-, Nrf2 KO
• Gene: Nfe2l2 Location: Chr2:75505857-75534985 bp, - strand Genetic Position: Chr2, 44.75 cM
• Alliance: Nfe2l2^tm1Ywk page

Abnormal development of Nfe2l1^tm1Ywk/Nfe2l1^tm1Ywk Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk embryos with increased apoptosis

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37053
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 4.2 kb segment, includind part of exon 4 and all of exon 5, was replaced by an in-frame lacZ gene followed by a neomycin selection cassette. Northern blot analysis on RNA derived from various tissues confirmed that a fusion transcript was detectable in intestine of homozygous mice, but no wild-type transcript was detectable in any tissue. However, no fusion protein was detected by histochemical staining in any adult tissue. (J:37053)

Expression

In Mice Carrying this Mutation:	9 assay results 6 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	16 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Nfe2l2^tm1Ywk

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Nfe2l2 Mutation: 90 strains or lines available

References

• Original: J:37053 Chan K, et al., NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13943-8
• All: 228 reference(s)