Mmp14^tm1Ktry
Targeted Allele Detail

Summary

• Symbol: Mmp14^tm1Ktry
• Name: matrix metallopeptidase 14 (membrane-inserted); targeted mutation 1, Karl Tryggvason
• MGI ID: MGI:2386246
• Synonyms: Mmp13^tm1Ktry
• Gene: Mmp14 Location: Chr14:54669055-54679913 bp, + strand Genetic Position: Chr14, 27.79 cM
• Alliance: Mmp14^tm1Ktry page

Histology and immunohistology of growth zones in distal femur of Mmp14^tm1Ktry/Mmp14^tm1Ktry mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61685
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 0.5 kb of the gene including part of exon 4 was replaced with a neomycin resistance cassette via homologous recombination. Northern blot analysis of lung and heart from homozygous mutant mice confirmed the absence of gene expression. (J:61685)

Expression

In Structures Affected by this Mutation:

18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mmp14 Mutation: 44 strains or lines available

References

• Original: J:61685 Zhou Z, et al., Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4052-7
• All: 21 reference(s)