Slit1^tm1Matl
Targeted Allele Detail

Summary

• Symbol: Slit1^tm1Matl
• Name: slit guidance ligand 1; targeted mutation 1, Marc Tessier-Lavigne
• MGI ID: MGI:2386385
• Gene: Slit1 Location: Chr19:41588696-41732104 bp, - strand Genetic Position: Chr19, 34.99 cM
• Alliance: Slit1^tm1Matl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73904
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The endogenous locus was disrupted by the insertion of a cassette containing an endoplasmic reticulum KDEL retention sequence, a stop codon, an IRES-tauGFP fusion protein, and a floxed neo gene. Mice carrying this allele were bred with transgenic mice expressing cre recombinase to generate Slit1^tm1.1Matl (J:73904)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Slit1 Mutation: 70 strains or lines available

References

• Original: J:73904 Plump AS, et al., Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system. Neuron. 2002 Jan 17;33(2):219-32
• All: 5 reference(s)