Ptgdr^tm1Sna
Targeted Allele Detail

Summary

• Symbol: Ptgdr^tm1Sna
• Name: prostaglandin D receptor; targeted mutation 1, Shuh Narumiya
• MGI ID: MGI:2386956
• Synonyms: DP^-, DP1^-
• Gene: Ptgdr Location: Chr14:45088692-45096832 bp, - strand Genetic Position: Chr14, 22.59 cM
• Alliance: Ptgdr^tm1Sna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61023
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 2 via homologous recombination. RT-PCR analysis detected the presence of the neo insertion allele in homozygous mutant animals. Absence of protein function in homozygous mutants was confirmed by bioassay using tracheal smooth muscle samples. (J:61023)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ptgdr^tm1Sna

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptgdr Mutation: 29 strains or lines available

References

• Original: J:61023 Matsuoka T, et al., Prostaglandin D2 as a mediator of allergic asthma. Science. 2000 Mar 17;287(5460):2013-7
• All: 33 reference(s)