Irf4^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Irf4^tm1Mak
• Name: interferon regulatory factor 4; targeted mutation 1, Tak Mak
• MGI ID: MGI:2387941
• Synonyms: IRF-4-, IRF4-
• Gene: Irf4 Location: Chr13:30933209-30950959 bp, + strand Genetic Position: Chr13, 13.28 cM, cytoband A3.3
• Alliance: Irf4^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42683
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced by a neomycin selection cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of concanavalin A activated lymph nodes obtained from homozygous mutant mice. (J:42683)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Irf4 Mutation: 28 strains or lines available

References

• Original: J:42683 Mittrucker HW, et al., Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science. 1997 Jan 24;275(5299):540-3
• All: 80 reference(s)