Ltbp4^{Gt(U3Cre)1Vmel}
Gene trapped Allele Detail

Summary

• Symbol: Ltbp4^{Gt(U3Cre)1Vmel}
• Name: latent transforming growth factor beta binding protein 4; gene trap 1, Harald von Melchner
• MGI ID: MGI:2388061
• Synonyms: 3C7, Ltbp4S^-
• Gene: Ltbp4 Location: Chr7:27004561-27037117 bp, - strand Genetic Position: Chr7, 15.87 cM
• Alliance: Ltbp4^{Gt(U3Cre)1Vmel} page

Mutation origin

• Mutant Cell Line: 3C7
• Germline Transmission: Earliest citation of germline transmission: J:85162
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector Type: gene trap
• Mutation details: A retroviral gene trap vector, containing cre recombinase and U3 sequences, integrated into intron 5 in a reverse transcriptional orientation. A 98% reduction in mRNA levels was identified in homozygous mutant mice by Northern blot analysis. Western blot analysis results were correlative. The insertion of the vector is thought to interfere with the splicing of this gene. (J:47007, J:78819)

Expression

In Structures Affected by this Mutation:

18 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ltbp4^{Gt(U3Cre)1Vmel}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ltbp4 Mutation: 120 strains or lines available

References

• Original: J:78819 Sterner-Kock A, et al., Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer. Genes Dev. 2002 Sep 1;16(17):2264-73
• All: 15 reference(s)