Gt(ROSA)26Sor^tm1(FLP1)Dym
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1(FLP1)Dym
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Susan Dymecki
• MGI ID: MGI:2429412
• Synonyms: CAGGS-Flpe, flipper, FLP, FLP deleter, FLPe, FLPeR, R26^Fki, R26^FLPe, ROSA26^Fki, ROSA26::FLPe knock in
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1(FLP1)Dym page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66893
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Gt(ROSA)26Sor^tm1(FLP1)Dym expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gt(ROSA)26Sor (MGI:104735)

• Mutation details: An enhanced flp cassette containing a splice acceptor site was ligated to a downstream PGK-neo cassette and inserted at the endogenous locus. Efficient frt-specific recombination in transgenic mice carrying a reporter gene was reported to reflect constituitive expression of the Gt(ROSA)26Sor from preimplantation onward. (J:66893, J:92442)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gt(ROSA)26Sor (mouse) Summary of all recombinase alleles driven by Gt(ROSA)26Sor. Comparative matrix view of recombinase activities Alliance mouse Gt(ROSA)26Sor gene page

Tumor Data

List all tumor models in MMHCdb carrying Gt(ROSA)26Sor^tm1(FLP1)Dym

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:66893 Farley FW, et al., Widespread recombinase expression using FLPeR (Flipper) mice. Genesis. 2000 Nov-Dec;28(3-4):106-10
• All: 833 reference(s)