Atf1^tm1Gsc
Targeted Allele Detail

Summary

• Symbol: Atf1^tm1Gsc
• Name: activating transcription factor 1; targeted mutation 1, Gunther Schutz
• MGI ID: MGI:2445229
• Synonyms: ATF1^-
• Gene: Atf1 Location: Chr15:100125729-100159129 bp, + strand Genetic Position: Chr15, 56.22 cM, cytoband F3
• Alliance: Atf1^tm1Gsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74982
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Homologous recombination of a construct containing lacZ and neo resulted in the deletion of a portion of exon 3 and all of exons 4 through 7. The targeted region encoded amino acids 200 through 1380, corresponding to the protein kinase A and leucine zipper domains. Protein was undetected in homozygous mutant mice by Western blot analysis of kidney, liver, and testis tissues. Beta-galactosidase staining showed the expression pattern of lacZ to be similar to that of the endogenous gene. (J:74982)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atf1 Mutation: 209 strains or lines available

References

• Original: J:74982 Bleckmann SC, et al., Activating transcription factor 1 and CREB are important for cell survival during early mouse development. Mol Cell Biol. 2002 Mar;22(6):1919-25
• All: 5 reference(s)