Irf9^tm1Ttg
Targeted Allele Detail

Summary

• Symbol: Irf9^tm1Ttg
• Name: interferon regulatory factor 9; targeted mutation 1, Tadatsugu Taniguchi
• MGI ID: MGI:2446102
• Synonyms: IRF-9^-, p48^-
• Gene: Irf9 Location: Chr14:55841442-55847487 bp, + strand Genetic Position: Chr14, 28.19 cM
• Alliance: Irf9^tm1Ttg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77456
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Two exons encoding the DNA binding domain (amino acids 1 through 121) were replaced by a neomycin resistance cassette. Electrophoretic mobility shift assay indicated the loss of Ifna induced activity. (J:77456)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Irf9 Mutation: 40 strains or lines available

References

• Original: J:77456 Kimura T, et al., Essential and non-redundant roles of p48 (ISGF3 gamma) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies. Genes Cells. 1996 Jan;1(1):115-24
• All: 44 reference(s)