Blnk^tm1Pjln
Targeted Allele Detail

Summary

• Symbol: Blnk^tm1Pjln
• Name: B cell linker; targeted mutation 1, Peter J Nielsen
• MGI ID: MGI:2447161
• Synonyms: Slp65^-, SLP-65^-
• Gene: Blnk Location: Chr19:40917371-40982664 bp, - strand Genetic Position: Chr19, 34.26 cM
• Alliance: Blnk^tm1Pjln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58740
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 4 and flanking intronic sequences with a neomycin resistance cassette. Northern blot analysis of splenocyte RNA revealed low levels of an aberrantly spliced transcript, however Western blot analysis detected no protein product. (J:58740)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Blnk^tm1Pjln

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Blnk Mutation: 78 strains or lines available

References

• Original: J:58740 Jumaa H, et al., Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65. Immunity. 1999 Nov;11(5):547-54
• All: 24 reference(s)