Tg(SV40-BCL2L1)169Nnz
Transgene Detail

Summary

• Symbol: Tg(SV40-BCL2L1)169Nnz
• Name: transgene insertion 169, Gabriel Nunez
• MGI ID: MGI:2447590
• Synonyms: bcl-xL, Tg(SV40-BCL2L1)1Nnz
• Transgene: Tg(SV40-BCL2L1)169Nnz Location: unknown
• Alliance: Tg(SV40-BCL2L1)169Nnz page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL/J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(SV40-BCL2L1)169Nnz expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BCL2L1 (598)

  Bcl2l1

  (MGI:88139)

• Mutation details: The transgene consists of an SV40 promoter, Igh enhancer, and a human BCL2L1 cDNA. The Igh enhancer was used to target transgene expression to T lymphocytes. Western blot analysis verified transgene expression in the thymus. (J:30597)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Seven transgenic founders were created and transgenic lines were established. Lines bcl-x-169 and bcl-x-86 were used for analysis.

References

• Original: J:30597 Grillot DA, et al., Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice. J Exp Med. 1995 Dec 1;182(6):1973-83
• All: 3 reference(s)