Muc1^tm1Gend
Targeted Allele Detail

Summary

• Symbol: Muc1^tm1Gend
• Name: mucin 1, transmembrane; targeted mutation 1, Sandra J Gendler
• MGI ID: MGI:2447730
• Synonyms: Muc-1-, Muc1-
• Gene: Muc1 Location: Chr3:89136364-89140688 bp, + strand Genetic Position: Chr3, 39.02 cM
• Alliance: Muc1^tm1Gend page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30128
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A lacZ-neo construct was inserted in frame into exon 1, placing the reporter under the control of the endogenous promoter. Transcript was undetected by Northern blot analysis of homozygous mutant mice. A lack of normal protein was indicated by immunohistochemical analysis of secretory epithelial tissue obtained from homozygous mutant mice. The authors reported that the expression of lacZ did not recapitulate endogenous expression. (J:30128)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Muc1 Mutation: 39 strains or lines available

References

• Original: J:30128 Spicer AP, et al., Delayed mammary tumor progression in Muc-1 null mice. J Biol Chem. 1995 Dec 15;270(50):30093-101
• All: 39 reference(s)