Tg(tetO-Utrn)1Ked
Transgene Detail

Summary

• Symbol: Tg(tetO-Utrn)1Ked
• Name: transgene insertion 1, Kay E Davies
• MGI ID: MGI:2448084
• Synonyms: Tg(UTR-TET)Ked, Utr-TET
• Transgene: Tg(tetO-Utrn)1Ked Location: unknown
• Alliance: Tg(tetO-Utrn)1Ked page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: A full-length cDNA encoding mouse utrophin with an N-terminal FLAG epitope tag was inserted between the cytomegalovirus (CMV) minimal promoter and polyadenylation signal, all downstream of the tetracycline operator (tetracycline responsive element). Tissue-specific tetracycline transactivator (tTA) or reverse transactivator (rtTA) expression from a second transgene permits regulation of utrophin expression by administration of doxycycline in drinking water. (J:80809)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available

References

• Original: J:80809 Squire S, et al., Prevention of pathology in mdx mice by expression of utrophin: analysis using an inducible transgenic expression system. Hum Mol Genet. 2002 Dec 15;11(26):3333-44
• All: 1 reference(s)