Grm7^{Tg(SMN2)89Ahmb}
Transgenic Allele Detail

Summary

• Symbol: Grm7^{Tg(SMN2)89Ahmb}
• Name: glutamate receptor, metabotropic 7; transgene insertion 89, Arthur H M Burghes
• MGI ID: MGI:2448989
• Synonyms: SMN2, Tg(SMN2)89Ahmb
• Gene: Grm7 Location: Chr6:110622542-111544191 bp, + strand Genetic Position: Chr6, 51.19 cM
• Alliance: Grm7^{Tg(SMN2)89Ahmb} page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Hypomorph, Inserted expressed sequence)
• Mutation: Insertion
• Grm7^{Tg(SMN2)89Ahmb} expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SMN2 (6607)

  Smn1	(MGI:109257)

• Mutation details: A 35.5 kb genomic fragment containing the human survival motor neuron 2 (SMN2) gene and promoter was used for the transgene. The transgene is ubiquitously expressed in all tissues examined by Northern blot analysis. Line 89 carries 1 copy of the transgene integrated into intron 4 of the gene. RT-PCR confirmed reduced expression of the gene the transgene is integrated into. (J:60592, J:174332)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 34 strains available Cell Lines: 0 lines available
• Carrying any Grm7 Mutation: 125 strains or lines available

References

• Original: J:60592 Monani UR, et al., The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy. Hum Mol Genet. 2000 Feb 12;9(3):333-9
• All: 224 reference(s)