Tg(Lck-icre)3779Nik
Transgene Detail

Summary

• Symbol: Tg(Lck-icre)3779Nik
• Name: transgene insertion 3779, Nigel Killeen
• MGI ID: MGI:2655492
• Synonyms: dLck-hcre³⁷⁷⁹, Tg(Lck-cre)3779Nik
• Transgene: Tg(Lck-icre)3779Nik Location: unknown
• Alliance: Tg(Lck-icre)3779Nik page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Lck-icre)3779Nik expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Lck

• Mutation details: This transgene expresses the codon-improved cre recombinase (icre) open reading frame under the control of the distal Lck promoter (dLck). This transgene is expressed in T cells primarily after Tcra locus rearrangement and the cells have reached the TCR^hi stage of development. (J:73479, J:99042)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lck (species not specified) Summary of all recombinase alleles driven by Lck. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

This transgene is used in J:73479, but specific details are published in J:99042.

References

• Original: J:73479 Wang Q, et al., Homeostatic competition among T cells revealed by conditional inactivation of the mouse Cd4 gene. J Exp Med. 2001 Dec 17;194(12):1721-30
• All: 71 reference(s)