Tlr9^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Tlr9^tm1Aki
• Name: toll-like receptor 9; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:2660562
• Synonyms: Tlr9-, TLR9 KO
• Gene: Tlr9 Location: Chr9:106099797-106104075 bp, + strand Genetic Position: Chr9, 57.46 cM
• Alliance: Tlr9^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66049
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.0 kb fragment of the gene encoding a part of a leucine-rich repeat domain was replaced with a neomycin resistance cassette. Northern blot analysis demonstrated that a mutated transcript was expressed from this allele, but this transcript is not expected to produce a functional protein. (J:66049)

Disease models

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Tlr9 Mutation: 66 strains or lines available

References

• Original: J:66049 Hemmi H, et al., A Toll-like receptor recognizes bacterial DNA. Nature. 2000 Dec 7;408(6813):740-5
• All: 461 reference(s)