Ace2^tm1Pngr
Targeted Allele Detail

Summary

• Symbol: Ace2^tm1Pngr
• Name: angiotensin converting enzyme 2; targeted mutation 1, Josef M Penninger
• MGI ID: MGI:2661723
• Gene: Ace2 Location: ChrX:162922338-162971414 bp, + strand Genetic Position: ChrX, 76.12 cM, cytoband F5
• Alliance: Ace2^tm1Pngr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77232
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 9 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region (nt 1069 through 1299) encoded the zinc binding catalytic domain. Northern and Western blot analyses indicated that neither transcript nor protein are produced by the mutant allele. (J:77232)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ace2 Mutation: 66 strains or lines available

References

• Original: J:77232 Crackower MA, et al., Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. 2002 Jun 20;417(6891):822-8
• All: 68 reference(s)